Treatment of Localized Osteosarcoma and Undifferentiated Pleomorphic Sarcoma (UPS) of Bone

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of newly diagnosed localized osteosarcoma and UPS of bone may include the following:

• Surgery to remove the primary tumor.
• Chemotherapy may be given before or after surgery to remove the primary tumor.
• Radiation therapy if surgery cannot be done or if the tumor was not completely removed by surgery.
• A clinical trial comparing combination chemotherapy with or without the addition of cabozantinib in treating patients with newly diagnosed localized or metastatic osteosarcoma.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.